New Vaginal Dryness Compounds

Update on Compounded Options for Vaginal Dryness

A non-hormonal treatment option shows promise

Hyaluronic acid/Vitamin E/Vitamin A Vaginal Creamalt

In 2008, a study was published that utilized a vaginal suppository containing hyaluronic acid sodium salt 5 mg, vitamin E acetate 1 mg, and vitamin A palmitate 1 mg. Dosing was a suppository intravaginally every night for 14 nights, then tapering to every other night for 14 nights. Of 150 women, 126 women completed the study in full. The study assessed efficacy of the study medication in the areas of burning, itching, inflammation and irritation. Results showed that any symptom that was reported as severe initially was resolved to either mild or absent at the end of four weeks.

Hyaluronic acid helps to form an extracellular water film, which moisturizes the skin, maintaining a water balance aiding in skin elasticity. It also facilitates the healing process and tissue regeneration. Vitamin E, which has antioxidant properties, also acts as an anti-inflammatory and healing agent. Vitamin A has been shown to increase the function of the immune local cells and the epithelium of the vagina.

DHEA Vaginal Cream

Dehydroepiandrosterone (DHEA) has been studied for libido and sexual dysfunction in postmenopausal women. Intravaginal doses studied include 3.25 mg, 6.5 mg, and 13 mg versus placebo. A parameter of this 2009 study considered the benefit of intravaginal DHEA on vaginal atrophy, dryness, and itching. Results showed that at the end of 12 weeks, all three doses had an equal benefit on vaginal dryness and no adverse events were reported. On the domain of arousal lubrication, the 13 mg dose achieved the best score, although all three doses showed tremendous benefit at 12 weeks. Serum steroid levels were evaluated in a separate study and found to be within the normal postmenopausal range.

These two new treatment options provide even more compounded choices if you suffer from vaginal atrophy in addition to our Estriol 0.1% Vaginal Cream. It is reasonable to assume that the addition of DHEA to the estriol vaginal cream may produce even greater effect although this combination has not been studied. The most exciting part of this is the Hyaluronic acid/Vitamin A & E combination. This can be particularly useful in women with a history of breast or uterine cancer for whom even intravaginal hormones are contraindicated providing much needed relief.

PLEASE NOTE: All compounded vaginal creams require a prescription from a qualified healthcare provider (MD, PA, APRN). 

We have created a downloadable prescription form that your healthcare provider may complete. It MUST be faxed from your provider's office or the original can mailed to us. Your healthcare provider can also call in your prescription to us.

For information about any of these compounded medications just call or email us.

Shipping Information


We are only able to ship prescription medications to the following states:

Colorado, Indiana, Iowa, Kansas, Massachusetts, Minnesota, Nebraska, New York, Pennsylvania and South Dakota

State shipping restrictions do not apply to over the counter supplements or hormone test kits.

Please check back as we continue to obtain pharmacy licenses in other states.

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